| Past Issue | Volume 6, Number 2, 2004 | | Comparison of Outcomes and Predictors of Trabeculectomy Using High-dose or Low-dose Mitomycin C |
Mario V Aquino, Ma Margarita L Lat-Luna, John Vincent Policarpio D Flores
Department of Ophthalmology and Visual Sciences, University of The Philippines Manila,
Philippine General Hospital, Manila, The Philippines
Aims: To compare the outcomes of trabeculectomy using low-dose or high-dose mitomycin C and to determine the factors that predict the postoperative intraocular pressure.
Patients and Methods: In a prospective, randomised comparative study, patients undergoing trabeculectomy were randomly assigned to receive either mitomycin C 0.2 mg/mL for 4 minutes or mitomycin C 0.4 mg/mL for 2 minutes. The intraocular pressure, bleb character, and occurrence of complications were compared. Age and sex of the patients, preoperative intraocular pressure, mitomycin C concentration, bleb characteristics, angle status, and age of the surgery were analysed to determine whether they were predictive factors for postoperative intraocular pressure.
Results: Seventy four eyes of 68 patients at the Philippine General Hospital underwent trabeculectomy between January and June 1997. Thirty six eyes were treated with mitomycin C 0.2 mg/mL while 38 eyes were treated with mitomycin C 0.4 mg/mL. There were no statistically significant differences in the mean preoperative and postoperative intraocular pressures, and in the mean percent change in intraocular pressures between the 2 groups. Analysis of variance showed that preoperative intraocular pressure and bleb characteristics were significant predictors of postoperative intraocular pressure.
Conclusions: There is no apparent difference in the outcomes of trabeculectomies using low-dose and high-dose mitomycin C. Preoperative intraocular pressure and bleb characteristics are predictive factors of postoperative intraocular pressure.
Key Words: Filtering surgery, Glaucoma, Mitomycin C
Asian J Ophthalmol 2004;6(2):2-5.
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